How the developing mammalian kidney assembles its thousands of nephrons: Fgfs as stemness signals.
نویسنده
چکیده
In this issue of Developmental Cell, Barak et al. (2012) identify a critical role for Fgf9 and Fgf20 signaling in the nephron progenitors of the developing mammalian kidney. These Fgfs serve as survival and nephron-forming competence signals for purified Six2+ cells that represent the progenitors that normally go on to generate nephrons.
منابع مشابه
Kidney Development: Roles of Sprouty, Wnt2b and Type Xviii Collagen in the Ureteric Bud Morphogenesis
The mammalian metanephric kidney develops through ureteric bud branching morphogenesis and tubule formation and involves secreted inductive signals and possibly their antagonists to regulate the process. Sprouty (spry) genes encode antagonists of FGFs and the EGF signalling pathways. To get an insight to potential developmental roles of the spry genes, the expression of spry1, 2 and 4 was analy...
متن کاملThe skate weighs in on kidney regeneration.
Research into kidney organogenesis has seen dramatic growth in recent years, fueled not only by new data on epithelial cell differentiation and the function of genes expressed in the kidney but also by a renewed interest in stem cell biology and its potential application to treating disease. Since the pioneering work of Grobstein in the middle 1950s (1), it has been known that the formation of ...
متن کاملSignaling during Kidney Development
The kidney plays an essential role during excretion of metabolic waste products, maintenance of key homeostasis components such as ion concentrations and hormone levels. It influences the blood pressure, composition and volume. The kidney tubule system is composed of two distinct cell populations: the nephrons forming the filtering units and the collecting duct system derived from the ureteric ...
متن کاملCanonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
The mammalian kidney is composed of thousands of individual epithelial tubules known as nephrons. Deficits in nephron number are associated with myriad diseases ranging from complete organ failure to congenital hypertension. A balance between differentiation and maintenance of a mesenchymal progenitor cell population determines the final number of nephrons. How this balance is struck is poorly ...
متن کاملA fish model of renal regeneration and development.
The fish kidney provides a unique model for investigating renal injury, repair, and development. Like mammalian kidneys, fish kidneys have the remarkable ability to repair injured nephrons, designated renal regeneration. This response is marked by a recovery from acute renal failure by replacing the injured cells with new epithelial cells, restoring tubule integrity. In addition, fish have the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Developmental cell
دوره 22 6 شماره
صفحات -
تاریخ انتشار 2012